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Year : 2022  |  Volume : 26  |  Issue : 3  |  Page : 189-192

Chronic low-dose exposure to highly toxic gas phosgene and its effect on peak expiratory flow rate

1 Department of Environmental Epidemiology, ICMR-National Institute for Research in Environmental Health, Bhopal, Madhya Pradesh, India
2 Department of Industrial Hygiene, CMR- Regional Occupational Health Centre (Southern), Bengaluru, Karnataka, India

Correspondence Address:
Dr. Rajnarayan R Tiwari
ICMR-National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhauri, Bhopal, Madhya Pradesh - 462 030
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijoem.ijoem_417_20

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Introduction: Phosgene is a highly toxic gas causing irritation of the airways and eyes though at high dose exposure. The effect on airways can be assessed by peak expiratory flow rate (PEFR) which is a cheaper, simple, and easy to perform test under field conditions and routine monitoring. Thus, this study is undertaken to understand the effect of chronic low-dose phosgene exposure on PEFR and the associated factors. Methods: This study included 287 workers of phosgene production and captive units. After recording the demographic, occupational, and clinical history on a questionnaire, every participant was subjected to clinical examination, chest radiography, and measurement of PEFR using Spirovit SP-10. Results: The mean age and mean duration of the job of participants was 42.8 ± 10.4 years and 18.9 ± 9.6 years, respectively. The PEFR was significantly reduced with increasing age, increasing duration in the job, and those having direct exposure. Conclusion: PEFR is affected by chronic low-dose exposure to phosgene.


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